Sr. Scientist I – Assay Development, Biology

Department: Biology
Location: San Diego
FLSA Status: Exempt


RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC). Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

Job Description

The role offers an opportunity to advance a pipeline of novel Radiopharmaceutical therapies from target selection through candidate nomination. The ideal candidate will have excellent communication and presentation skills and will be a highly motivated biologist with a broad technical skill set to support design and execution of experiments in a drug discovery setting. The role will have an opportunity to work on multiple projects ranging from target selection through candidate nomination stages and can be expected to lead early-stage projects in an interdisciplinary setting. The role is technical and will need a person who enjoys leading from the bench with strong experimental and data analysis skills and a comfort level in working under tight timelines. The role requires an ability and willingness to work with radioactive isotopes.

Job Responsibilities

Essential duties and responsibilities include the following.  Other duties may be assigned.

  • Conceptualize and execute in vitro assays which contribute to answering key biological questions on project and support the screening, characterization, and lead-identification of novel RPT agents.
  • Utilize a deep understanding of cancer biology and oncology drug development to support the target selection and initiation of new TRP projects.
  • Work in close collaboration with interdisciplinary team members to provide needed biology support to guide programs through lead identification/optimization phases.
  • Support the overall biology screening and evaluation plan, work closely with chemists, DMPK, imaging and in vivo teams to ensure implementation of screening funnel and appropriate prioritization of experiments.
  • Work under the guidance of clinical, translational leads to help implement the translational biology plan to support the clinical development strategy.
  • Help generate, review technical reports in support of regulatory submissions and support the publication/presentation plans with active contributions.
  • Identify external partners, KOLs, outside expertise that will help advance the pipeline.
  • Supervise the work of junior scientists and ensure experimental rigor and high quality.

Education and Experience

  • PhD in cancer biology, cell biology, pharmacology, or a related field and a deep understanding of cancer biology and experience working in oncology drug development is ideal. Exceptional BS/MS candidates with strong track record of scientific accomplishments in industrial settings will also be considered.
  • PhD 2 + years or BS with 7+ years of experience in pharmaceutical/biotech R&D environments demonstrating successful accomplishments and progressive leadership and broadening responsibilities.
  • Experience in working on targeted cancer therapy modalities such as RPTs, ADCs, PDCs is highly desirable.

Skills and Qualifications

  • Expertise with invitro, cell-based assay development and optimization and proficiency with Cell culture, molecular biology techniques, ELISA, flow-cytometry, western blot, qPCR, single-cell cloning, immunohistochemistry and related protocols.
  • Ability to effectively partner with chemistry/DMPK, imaging and in vivo teams and ability to effectively interpret data and plan experiments accordingly.
  • Strong technical problem-solving skills and a basic familiarity with ADME/PK concepts, drug design and the use of appropriate in vivo oncology models is critical.
  • Excellent written and oral communication and presentation skills and ability to work in a fast-paced, dynamic, and collaborative environment.
  • Ability to work with radioisotopes with strict adherence to radiation safety protocols.
  • Demonstrated ability to supervise and effectively guide the work of junior scientists and demonstrated ability of productivity in an industrial drug discovery setting.

Physical Demands

While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 30 pounds. Specific vision abilities required by this job include close vision and distance vision.

This is a position that requires working in a laboratory environment, protective clothing, gloves, and safety glasses are required while working in a laboratory environment with radioactive materials.

Work Environment

The noise level in the work environment is usually moderate.

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