Nicholas Smith has more than 20 years of drug discovery experience in the pharmaceutical industry. Most recently at Metacrine Inc., he was a Senior Vice-President of Chemistry and oversaw the chemistry, DMPK and Intellectual Property groups.
Prior to Metacrine, he was at Seragon Pharmaceuticals and Aragon Pharmaceuticals, where he was Vice President of Chemistry and oversaw medicinal chemistry projects, including the development of two estrogen receptor degrader clinical candidates, and a next-generation androgen receptor antagonist program. In addition, Dr. Smith was responsible for the Aragon and then Seragon intellectual property portfolios and aspects of clinical manufacturing.
Prior to Aragon, he was Head of Chemistry at Kalypsys Pharmaceuticals. Prior to Kalypsys, Dr. Smith was a Research Fellow at Merck & Co., where he led chemistry groups that contributed to clinical candidates in the areas of obesity and inflammation.