Location: San Diego
Job Summary
The Associate Scientist I/II Translation Biology role offers an opportunity to help bridge laboratory research with clinical applications to advance novel Radiopharmaceutical Oncology therapies. As a translational scientist, you will develop and execute in vitro, ex vivo, and in vivo models that recapitulate human cancer biology to identify tumor indications, test rational therapeutic combinations, and understand mechanisms of radio-resistance. The ideal candidate will be a critical thinker and a technical problem solver who enjoys working in interdisciplinary team settings. The role requires an ability and willingness to work with radioactive isotopes.
Job Responsibilities
Essential duties and responsibilities include the following. Other duties may be assigned.
- Develop, optimize and utilize preclinical in vitro and in vivo models that mimic human cancer biology to evaluate drug efficacy, mechanism of action, and resistance mechanisms.
- Help develop and run cell- and tumor-based assays to support rational combination strategies, identification of mechanisms of resistance to RPT agents, selection of lead tumor indications, and identification of potential biomarkers that predict patient response to therapies.
- Work with radioactivity in various assays in strict adherence to the radiation safety protocols.
- Work under the guidance of project team leaders to support the overall translational plan; work closely with biology, chemistry, DMPK, imaging and in vivo teams to ensure appropriate prioritization of experiments.
- Generate, organize, and maintain meticulous records on all conducted experiments. Independently analyze and interpret data and present experimental plans and results at project team meetings, group meetings, and company meetings.
- Actively contribute to the experimental design and planning efforts to help achieve project goals under tight timelines.
- Collaborate with colleagues in other functional areas including biology and chemistry.
- Assist in laboratory operation management duties.
Education and Experience
- BS with 4+ years of experience or MS 2+ years of experience within Cancer Biology, Molecular/Cell biology, Pharmacology, or a related discipline with hands-on laboratory experience.
- Hands-on expertise with human tumor-based assays and cell-based instruments (e.g. IncuCyte and Flow Cytometers) are required.
- Prior experience of working on drug discovery projects in an industrial setting is highly desirable.
Skills
- Ability to work with radioisotopes with strict adherence to radiation safety protocols.
- Ability to execute experiments, including preclinical model development (e.g., cell lines, animal models, patient-derived models), to investigate disease mechanisms and evaluate therapeutic interventions.
- Familiarity and hands on experience with invitro, cell-based assay development and optimization and proficiency with cell culture, molecular biology techniques, ELISA, flow-cytometry, western blot, qPCR, immunohistochemistry and related protocols.
- Creativity and adaptability to explore new research methodologies, technologies, and approaches that enhance translational research outcomes.
- Familiarity with drug development process and interfacing and working with interdisciplinary teams.
- Excellent written and oral communication and presentation skills and ability to work in a fast-paced, dynamic, and collaborative environment.
- Strong interpersonal, organizational and communication skills.
- Proficiency in data analysis techniques, including statistical methods.
Physical Demands:
While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 30 pounds. Specific vision abilities required by this job include close vision and distance vision.
This is a position that requires working in a laboratory environment, protective clothing, gloves, and safety glasses are required while working in a laboratory environment with radioactive materials.
Work Environment:
The noise level in the work environment is usually moderate.
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