Head of Biology & Translational Science

Location: San Diego


RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC).  Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.


A key member of an entrepreneurial leadership team with a shared vision to build the leading radiopharmaceutical company. The ideal candidate will possess a deep knowledge of cancer biology and a record of achievement in oncology drug discovery and development.  The role needs an accomplished, confident leader with hands-on experience of successfully advancing programs from discovery through lead optimization and IND submissions.  The role requires an ability to lead and grow the in vitro/in vivo biology team in support of the pipeline growth while creating a results-oriented culture that emphasizes cooperation, teamwork, and respect.  The role is expected to serve as the bridge between the discovery and clinical sciences for implementing a translational strategy for the programs in the development pipeline.   

Job Responsibilities

Essential duties and responsibilities include the following.  Other duties may be assigned.

  • Provide strategic and operational leadership for the in vitro and in vivo biology teams.
  • Build and grow the biology teams to support pipeline growth, foster a data driven, results-oriented culture and a high functioning team with strong emphasis on teamwork and cooperation. Identify and mentor promising scientists for leadership roles and create suitable career growth opportunities for aspiring scientists.
  • Utilize a deep understanding of cancer biology and oncology drug development to lead the efforts on target selection and initiation of new RPT projects.
  • Work in close collaboration with interdisciplinary teams to provide functional biology leadership to guide programs through lead identification/optimization phases.
  • Develop preclinical GLP/non-GLP data packages to support regulatory submissions and clinical development.
  • Work closely with clinical science, clinical operations, and medical affairs teams to develop a translational strategy to support clinical development programs.
  • Build relationships with a network of KOLs/thought leaders and identify external resources for potential partnerships and collaborations.
  • Author/review study reports and regulatory documentation, scientific presentations and publications manage external research collaborations.
  • Create and manage department and project budgets, internal, external resources in support of corporate goals.

Education and Experience

  • PhD in biology, pharmacology, or a related field
  • 15 + years of leadership experience in pharmaceutical/biotech R&D environments.
  • Demonstrated ability to build and lead high functioning discovery biology and translational teams and a track record of getting things done in small biotech settings.
  • Deep understanding of cancer biology and oncology drug development and a demonstrated ability to advance programs from discovery through lead optimization and IND filings.
  • Experience in leading targeted cancer therapies such as TRPs, ADCs, PDCs is highly desirable. 
  • Experience with analysis of preclinical and clinical datasets, biomarker technologies and an ability to implement precision medicine strategies in clinical settings.
  • Solid understanding of FDA, EMA and relevant regulatory guidance for oncology drug development.

Skills and Qualifications

  • Excellent written and oral communication skills and ability to work in a fast-paced, dynamic, and collaborative environment.
  • High EQ, Strong interpersonal, organizational and communication skills and ability to motivate and drive productivity in small company environments.
  • Ability to effectively partner with Clinical, regulatory, CMC and chemistry/DMPK teams.
  • Ability to successfully establish and manage external collaborations including CROs and academic and industrial collaborations.

Physical Demands

While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 25 pounds. Specific vision abilities required by this job include close vision and distance vision. 

This is a position that requires working in a laboratory environment, protective clothing, gloves, and safety glasses are required while working in a laboratory environment with radioactive materials.

Work Environment

The noise level in the work environment is usually moderate.

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