Scientist I, Radiochemistry

Location: San Diego


The Scientist will be responsible for conducting research, experiments, and analysis in the field of radiochemistry. This role involves radiolabeling of diagnostic and therapeutic radioisotopes of peptides, small molecules, and/or antibodies as well as quality testing for in vitro and in vivo work. The Scientist will work in laboratory settings, collaborating with interdisciplinary teams to advance scientific knowledge and contribute to the advancement of all RayzeBio’s internal programs.

Job Responsibilities

Essential duties and responsibilities include the following.  Other duties may be assigned.

  • Develop and optimize experimental procedures ad methods, as well as conduct experiments to radiolabel peptides, small molecules and/or antibodies using various isotopes including but not limited to: Lu-177, Ac-225, Cu-64, Ga68 and Zr89
  • Develop and execute methods for the characterization of radiolabeled compounds, using techniques such as radio-HPLC and radio-TLC chromatography to analyze purity and stability
  • Develop novel methods and conduct in vitro assays (e.g. plasma stability and metabolite analysis) with radiolabeled compounds
  • Prepare compounds for cell-binding assays and in vivo biodistribution and dosimetry studies
  • Evaluate and present all radiolabeling methods and analytical results in functional meetings to provide input to progress internal programs
  • Develop, interpret, and maintain appropriate documentation using GxP guidelines, including radiolabeling protocols, reports and data analyses
  • Maintain a clean and safe working environment

 Education and Experience

  • A Ph.D or Master’s degree in radiochemistry, chemistry, nuclear chemistry, or related field
  • A minimum of 5 years of experience in radiochemistry, radiopharmaceutical, and/or CMC development field
  • Demonstrated experience in radiochemistry techniques and quality control instruments including but not limited to radioHPLC, TLC, gamma counter, gamma spectroscopy
  • Proper radiation safety practices during radiosynthesis, radioanalytical chemistry operations, and when physically within the lab areas at all times
  • Ability to work both collaboratively and independently in a fast-paced and cross-functional environment

Skills and Qualifications

  • Hands on experience working with radioactive materials and radiation instrumentation in a radiochemistry laboratory setting.
  • Highly motivated and organized professional with the ability to work both with a team and independently
  • Multi-disciplined scientist with ability to troubleshoot
  • Excellent professional ethics, integrity, and ability to maintain confidential information

Physical Demands

While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 60 pounds. Specific vision abilities required by this job include close vision and distance vision. 

This is a position that requires working in a laboratory environment, protective clothing, gloves, and safety glasses are required while working in a laboratory environment with radioactive materials.

Work Environment

The noise level in the work environment is usually moderate.

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