Location: San Diego
Job Summary
The laboratory-based role offers an opportunity to help advance novel Radiopharmaceutical therapies from laboratory into clinical testing. The candidate is responsible for developing and running surface plasmon resonance (SPR) assays for compound screening to support various pipeline projects. The ideal candidate will be a critical thinker and a technical problem solver who enjoys working in interdisciplinary drug discovery teams. The role requires an ability and willingness to work with radioactive isotopes.
Key Responsibilities:
- Develop and optimize SPR and biosensor-based assays for the evaluation of biomolecular interactions, particularly in the context of oncology targets to support the screening, characterization, and lead-identification of novel RPT agents.
- Conduct routine screening experiments using SPR and biosensor platforms to generate high-quality data for project teams.
- Operate and maintain SPR and biosensor instruments, ensuring optimal performance and troubleshooting technical issues as needed.
- Generate, organize, and maintain meticulous records on all conducted experiments. Independently analyze and interpret data and present experimental plans and results at project team meetings, group meetings, and company meetings.
- Actively contribute to the experimental design and planning efforts to help achieve project goals under tight timelines.
- Work with radioactivity in various assays in strict adherence to the radiation safety protocols.
- Work under the guidance of project team leaders to support the overall biology screening and evaluation plan, work closely with chemists, DMPK, imaging and in vivo teams to ensure implementation of screening funnel and appropriate prioritization of experiments.
- Collaborate with colleagues in other functional areas including translational research and chemistry.
- Assist in laboratory operation management duties.
Education and Experience:
- BS with 4+ years of experience or MS 2+ years of experience within Biology, Biochemistry, Molecular Biology, or a related discipline with hands on laboratory experience.
- Proven experience in SPR and biosensor assay development and operation, ideally within the oncology field.
- Hands-on expertise with SPR instruments (e.g., Biacore 8k, ProteOn) and biosensor technologies (e.g., BLI, SPRi).
- Prior experience of working on drug discovery projects in an industrial or an academic setting is preferred.
Skills:
- Demonstrated expertise in the experimental design, running and data analysis of various SPR methodologies
- Proficient with a variety of ligand immobilization techniques, ligand regeneration conditions, and execution of epitope binning experiments
- Familiarity and hands on experience with in vitro, cell-based assay development and optimization and proficiency with cell culture, molecular biology techniques, ELISA, flow-cytometry, western blot, qPCR, single-cell cloning, immunohistochemistry and related protocols is a plus
- Excellent written and oral communication and presentation skills and ability to work in a fast-paced, dynamic, and collaborative environment.
- Strong interpersonal, organizational and communication skills
- Familiarity with drug development process and interfacing and working with interdisciplinary teams
- Ability to work with radioisotopes with strict adherence to radiation safety protocols.
The starting compensation for this job is a range from $92,601-$125,285, plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.
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