Location: San Diego
Background
RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC). Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.
Job Description
The laboratory-based role offers an opportunity to help advance novel Radiopharmaceutical therapies from laboratory into clinical testing. The candidate is responsible for developing and running biochemical and cell-based assays to support target validation, compound screening and mechanism of action studies for various pipeline projects. The ideal candidate will be a critical thinker and a technical problem solver who enjoys working in interdisciplinary drug discovery teams. The role requires an ability and willingness to work with radioactive isotopes.
Job Responsibilities
Essential duties and responsibilities include the following. Other duties may be assigned.
- Help develop and run biochemical and cell-based assays to support the screening, characterization, and lead-identification of novel RPT agents.
- Work with radioactivity in various assays in strict adherence to the radiation safety protocols.
- Work under the guidance of project team leaders to support the overall biology screening and evaluation plan, work closely with chemists, DMPK, imaging and in vivo teams to ensure implementation of screening funnel and appropriate prioritization of experiments.
- Generate, organize, and maintain meticulous records on all conducted experiments. Independently analyze and interpret data and present experimental plans and results at project team meetings, group meetings, and company meetings.
- Actively contribute to the experimental design and planning efforts to help achieve project goals under tight timelines.
- Collaborate with colleagues in other functional areas including translational research and chemistry.
- Assist in laboratory operation management duties.
Education and Experience
- BS with 3-10 years of experience or MS 2-4+ years of experience within Biology, Biochemistry, Molecular Biology, or a related discipline with hands on laboratory experience.
- Prior experience of working on drug discovery projects in an industrial or an academic setting is preferred.
Skills
- Familiarity and hands on experience with invitro, cell-based assay development and optimization and proficiency with Cell culture, molecular biology techniques, ELISA, flow-cytometry, western blot, qPCR, single-cell cloning, immunohistochemistry and related protocols.
- Excellent written and oral communication and presentation skills and ability to work in a fast-paced, dynamic, and collaborative environment.
- Strong interpersonal, organizational and communication skills
- Familiarity with drug development process and interfacing and working with interdisciplinary teams
- Ability to work with radioisotopes with strict adherence to radiation safety protocols.
Physical Demands:
While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 30 pounds. Specific vision abilities required by this job include close vision and distance vision.
This is a position that requires working in a laboratory environment, protective clothing, gloves, and safety glasses are required while working in a laboratory environment with radioactive materials.
Work Environment:
The noise level in the work environment is usually moderate.
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